P 450 - catalyzed asymmetric cyclopropanation of electron - deficient olefins under aerobic conditions † Hans Renata , Z . Jane Wang , Rebekah Z . Kitto and Frances
نویسندگان
چکیده
3640 | Catal. Sci. Technol., 2014, 4, 3640–3643 This journal is © The R Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., MC-210-41, Pasadena, CA, USA. E-mail: [email protected] † Electronic supplementary information (ESI) available: Experimental procedures for protein-catalyzed reactions and characterization of new compounds. See DOI: 10.1039/c4cy00633j Cite this: Catal. Sci. Technol., 2014, 4, 3640 Received 15th May 2014, Accepted 22nd June 2014
منابع مشابه
P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions.
A variant of P450 from Bacillus megaterium five mutations away from wild type is a highly active catalyst for cyclopropanation of a variety of acrylamide and acrylate olefins with ethyl diazoacetate (EDA). The very high rate of reaction enabled by histidine ligation allowed the reaction to be conducted under aerobic conditions. The promiscuity of this catalyst for a variety of substrates contai...
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